The most promising 150 private digital health startups working to transform the healthcare industry with new models of primary care to emerging tech solutions for providers.

Digital health startups are hot today. Can you name 10?

The digital healthcare startup I worked for was rolling out the first pulse oximeter of its kind, although not a digital tech startup in today’s terms. It was a healthcare tech startup.

From developing and product managing groundbreaking products like the first pulse oximeter, the first check-reader, the first digital security surveillance system to consulting with some of the top startups in the Boulder and Denver, Colorado, I’ve seen a lot of great insights to share.

Matrix Marketing Group loves working with this type of digital healthcare startup and sees its potential.

Hospitals are using decades-old processes that are a luxury that many hospitals can’t afford. Hospitals, like insurance companies, are commodified service for the most part. 

Hospitals need to use their assets better, and human capital is their biggest asset. It means improving operations. And that is done through knowledge and expertise only training can provide.

While it’s the IPOs of big-name tech firms that are making the headlines, a wave of smaller digital health startups are transforming the health care industry and are likely to go public sometime over the next 12 months. 

CB Insights’ first-ever annual cohort of Digital Health 150 startups is a list of 150 of the most promising private companies creating innovative products. Click To Tweet

They may not be all that well-known, but these startups have been in operation for close to a decade or more and are garnering investors’ attention (and cash), according to Business Insider.

Digital health startups include ZocDoc, 23andMe, HeartFlow, Modernizing Medicine, Livongo, Health Catalyst, Change Healthcare, Phreesia, and Peloton. 

Our friends recently discussed the top Digital Health 150 startups.

As these private digital healthcare startups begin to prove their products attributes through Alpha and beta testing there appears to be a great promise.

A total of 17 companies on the list are unicorns (private companies valued at $1B+). Click To Tweet

CB Insights’ first-ever annual cohort of Digital Health 150 startups is a list of 150 of the most promising private companies creating innovative products and services in the $5T+ healthcare industry, according to CB Insights’ Industry Analyst Consensus.

Our research team selected the 150 startups from a pool of 5K+ companies based on several factors, including patent activity, investor profile, news sentiment analysis, proprietary Mosaic scores, market potential, partnerships, competitive landscape, team strength, and tech novelty.

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For the purposes of this report, digital health is defined as companies in the healthcare space that use technology/software as a key differentiator from their competition.

This includes everything from disease diagnostics to tech-driven health insurance platforms to AI tools for drug discovery and more.

digital health startups

150 startups in different stages of R&D

The Digital Health 150 companies span a wide spectrum of categories that involve all three key stakeholder groups for the healthcare industry — providers, payers, and patients.

These companies range from emerging startups to established unicorns (companies with $1B+ valuations). The selected companies represent a mix of startups at different stages of funding and product commercialization.

top digital health startup

For example, China-based We Doctor has a valuation of $5.5B and provides primary care services that leverage its tech platforms and provider network.

In contrast, RDMD is an early-stage company specializing in drug discovery efforts for rare diseases. The company plans to aggregate data to help develop treatments for a range of conditions.

A total of 17 companies on the list are unicorns (private companies valued at $1B+). Of these, 12 companies are US-based, 3 are based in China, 1 is based in France, and 1 is based in the UK.

Most well-funded companies

The most well-funded companies on the Digital Health 150 list span a broad range of categories. The top-funded company is genomics startup GRAIL, followed by insurance tech player Oscar Health and then China-based We Doctor.

startups in healthcare

Startups outside the United States

Of the 150 selected digital health startups, 116 are headquartered in the US. Those based outside the US include 17 from Asia, 16 from Europe, and 1 from Canada.

healthcare and startups

After the US, China is the second most-represented country on this list, with 7 of the selected companies, and Israel is third with 4 companies.

Most active investors

Over 850 unique investors have funded this year’s Digital Health 150 cohort, including corporations, CVCs, VC firms, and angel investors.

Below, we highlight the top 10 most active investors among the companies selected. 

Themes & trends

Across our 150 selected companies, we identified key themes and trends that highlight their efforts to transform the healthcare industry.

Below, we discuss a selection of these trends across different categories.


Many companies on our list are leveraging AI and machine learning to help develop their respective software platforms.

From consumer health companies to imaging & diagnostics startups, AI is at the forefront of their products and services.

One example here is pathology — an area that AI has begun to transform. For instance, startups such as PathAI and PAIGE.AI are using AI to help speed up patient diagnosis.

Source: PAIGE.AI

AI is also being leveraged through drug discovery & development — accelerating the identification of new targets and therapeutic candidates.

An example here is OWKIN, a startup that develops algorithms to help interpret disease-related data and predict treatment outcomes.


As investments to women’s health startups have increased, we’ve seen startups targeting everything from egg freezing services to emerging tech for managing menopause.

In particular, fertility has gained traction as one of the main areas of interest for women.

Startups such as Ava Science (fertility tracking device) and Carrot Fertility (fertility supplemental insurance) are providing novel services that aim to boost accessibility and convenience.

Virtual care clinics such as Maven Clinic are also helping women gain better access to providers that cater specifically to women’s health needs and concerns.

Source: Maven Clinic

Maven raised a $27M Series B round in September 2018 with participating investors including Sequoia Capital and Oak HC/FT Partners, among others.


The growing size of the aging population is creating an increased demand for tech that aims to improve their health management.

This includes services targeted at both home care solutions and care coordination between providers.

One example here is ClearCare — a home care platform that aims to facilitate everything from administrative tasks to tracking patient hospitalizations.

Source: ClearCare


Population health has been generating a lot of buzz in healthcare. In particular, there’s a growing emphasis on leveraging social determinants of health (SDoH) to generate better health outcomes.

An example here is Unite Us, a New York-based startup working to build care networks that integrate SDoH into how healthcare is delivered.

Source: Unite Us

Its approach is to provide care coordination software that can handle external referrals and track patient outcomes, helping to connect healthcare with social services.


As more healthcare stakeholders look to collaboration to spur innovation in the industry, value-based care has come to the forefront.

In particular, payers and providers have established new care coordination networks to help reduce overall healthcare costs — with the goal of delivering care that provides better value to patients.

An example here is Vim, which provides patients with access to both payers and providers to make it easier to find appropriate care options.

Source: Vim

Vim raised a $24M Series B round in September, with participating investors including Optum Ventures, Premera Blue Cross, and Sequoia Capital, among others.


Concierge medicine startups, such as One Medical or Parsley Health, use a membership model to help offer patients elevated healthcare services experience.

The approach aims to offer faster health visits with providers and more predictable associated costs.

Recently, Galileo Health — started by the founder of One Medical — launched an app-based concierge medicine platform geared towards providing a comprehensive level of care, including for chronic disease management.

It raised funding from Oak HC/FT Partners in May.


Telehealth services have expanded in recent years to become more differentiated.

Primary care platforms such as Ada Health and 98point6 are helping patients access more tailored care from their smartphones.

The startup raised a $50M Series C in October 2018 from Goldman Sachs and Frazier Healthcare Partners.

Another example is Talkspace, which offers psychotherapy services delivered virtually. It has raised $109M in total disclosed funding from investors including Compound, Norwest Venture Partners, Spark Capital, and SoftBank, among others.

Other companies in this category use remote monitoring technology to supplement virtual care services.

Table of the Digital Health 150 companies

Read the original article here.

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General FAQ’s

What is a digital health startup?

Digital health startups are doing everything from enhancing patient-provider relationships to streamlining workflows within health systems, and they’re raising much money along the way.

How do digital health startups market themselves?

The digital health startups management team will go through stages, and for product launch, the target market, buyer’s journey, and personas all need to be created before launch.

How many digital health startups existed in 2019?

We found over 150 private digital healthcare startups with promise.


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